Immunology of gene therapy

Summarizes and presents a broad review of the latest immunological advances in the field of genetic therapy. The book's unique organization, which approaches the topic from a vector and target organ point of view, rather than from a disease-specific perspective, reflects the ways in which gene therapies are being investigated today. This provides scientists and physicians attempting to develop gene therapies with a powerful tool for comparing vectors and target organs side by side, making the right investigative and clinical choices, anticipating potential problems, modifying protocols, and obtaining a broader view of the issues. Each chapter covers local and systemic responses; strengths and characteristics of innate responses; strengths and characteristics of adaptive (i.e., T helper, cytotoxic T lymphocyte, and B cell/antibody) responses to the vector and to transgene products; and preexisting immunity in humans.